Noopept

Summary

Noopept (N-phenylacetyl-L-polyglycine ethyl ester) is a relatively new and promising nootropic compound that is known for its potent effects (Ostrovskaia, Gudasheva, Voronina & Seredenin, 2002). Noopept was formed based on its derivative action and similar pharmalogical properties to Piracetam, where Noopept requires one thousandth of the dose of Piracetam (Ostovskaia et al., 2002). Though Piracetam is able to accentuate early memory functions, Noopept works to facilitate the further memory processes of consolidation and retrieval, including spatial memory (Ostovskaia et al., 2002; Ostrovskaya et al., 2007). Noopepts actions can be pinned down to its antioxidant and anti-inflammatory effects as well as capacity to inhibit neurotoxicity caused by neuronal excitation caused by overabundant calcium and/or glutamate, and also produces improvements in microcirculation (Ostovskaia et al., 2002; Kovalenko et al., 2002a).

Benefits and Effects

Dosage

5mg to 10mg

Oral: Onset 15 to 30 minutes ~ Duration 3 to 6 hours

Sublingual: 5 to 10 minutes ~ Duration 3 to 6 hours

Intranasal: 0 to 5 minutes ~ Duration 3 to 6 hours (Tripsit, n.d.).

References

Jia, X., Gharibyan, A. L., Öhman, A., Liu, Y., Olofsson, A., & Morozova-Roche, L. A. (2011). Neuroprotective and nootropic drug Noopept rescues α-synuclein amyloid cytotoxicityJournal of molecular biology414(5), 699-712. DOI: 10.1016/j.jmb.2011.09.044

Kovalenko, L. P., Miramedova, M. G., Alekseeva, S. V., Gudasheva, T. A., Ostrovskaia, R. U., & Seredenin, S. B. (2002a). Anti-inflammatory properties of Noopept (dipeptide nootropic agent GVS-111)Eksperimental’naia i klinicheskaia farmakologiia65(2), 53-55.

Kovalenko, L. P., Smol’nikova, N. M., Alekseeva, S. V., Nemova, E. P., Sorokina, A. V., Miramedova, M. G., … & Kulakova, A. V. (2002b). Preclinical study of noopept toxicityEksperimental’naia i klinicheskaia farmakologiia65(1), 62-64.

Ostrovskaia, R. U., Gudasheva, T. A., Voronina, T. A., & Seredenin, S. B. (2002). The original novel nootropic and neuroprotective agent noopept. Eksperimental’naia i klinicheskaia farmakologiia65(5), 66-72. Retrieved from http://europepmc.org/abstract/med/12596521

Ostrovskaya, R. U., Gruden, M. A., Bobkova, N. A., Sewell, R. D., Gudasheva, T. A., Samokhin, A. N., … & Morozova-Roche, L. A. (2007). The nootropic and neuroprotective proline-containing dipeptide noopept restores spatial memory and increases immunoreactivity to amyloid in an Alzheimer’s disease modelJournal of psychopharmacology21(6), 611-619. DOI: 10.1177/0269881106071335

Ostrovskaya, R. U., Gudasheva, T. A., Zaplina, A. P., Vahitova, J. V., Salimgareeva, M. H., Jamidanov, R. S., & Seredenin, S. B. (2008). Noopept stimulates the expression of NGF and BDNF in rat hippocampusBulletin of experimental biology and medicine146(3), 334-337. DOI: /10.1007/s10517-008-0297-x

Ostrovskaya, R. U., Vakhitova, Y. V., Kuzmina, U. S., Salimgareeva, M. K., Zainullina, L. F., Gudasheva, T. A., … & Seredenin, S. B. (2014). Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylationJournal of biomedical science21(1), 74. DOI: 10.1186/s12929-014-0074-2

Tripsit. (n.d.). Noopept. Retrieved from http://drugs.tripsit.me/noopept#duration

 

 

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